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Sterilization of auto-crosslinked hyaluronic acid scaffolds structured in microparticles and sponges.
Shimojo, Andréa Arruda Martins; de Souza Brissac, Isabela Cambraia; Pina, Lucas Martins; Lambert, Carlos Salles; Santana, Maria Helena Andrade.
Afiliação
  • Shimojo AA; Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas-SP, Brazil.
  • de Souza Brissac IC; Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas-SP, Brazil.
  • Pina LM; Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas-SP, Brazil.
  • Lambert CS; Department of Applied Physics, Institute of Physics "Gleb Wataghin", University of Campinas, Campinas-SP, Brazil.
  • Santana MH; Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, Campinas-SP, Brazil.
Biomed Mater Eng ; 26(3-4): 183-91, 2015.
Article em En | MEDLINE | ID: mdl-26684890
This work evaluated the effects of UV irradiation, plasma radiation, steam and 70% ethanol treatments on the sterilization and integrity of auto-crosslinked hyaluronic acid (HA-ACP) scaffolds structured in microparticles and sponges aiming in vivo applications for regenerative medicine of bone tissue. The integrity of the microparticles was characterized by rheological behavior, while for the sponges, it was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. The effectiveness of the sterilization treatment was verified by the number of microorganism colonies in the samples after the treatments. In conclusion, plasma radiation was the best treatment for the sponges, while steam sterilization in the autoclave at 126°C (1.5 kgf/cm2) for 5 min was the best treatment for the microparticles.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterilização / Desinfecção / Nanopartículas / Alicerces Teciduais / Ácido Hialurônico Idioma: En Revista: Biomed Mater Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterilização / Desinfecção / Nanopartículas / Alicerces Teciduais / Ácido Hialurônico Idioma: En Revista: Biomed Mater Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda