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Functional Evidence for Memory Stabilization in Sensorimotor Adaptation: A 24-h Resting-State fMRI Study.
Della-Maggiore, Valeria; Villalta, Jorge I; Kovacevic, Natasa; McIntosh, Anthony Randal.
Afiliação
  • Della-Maggiore V; IFIBIO Houssay, Systems Neuroscience Group, Department of Physiology and Biophysics, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Villalta JI; IFIBIO Houssay, Systems Neuroscience Group, Department of Physiology and Biophysics, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Kovacevic N; Rotman Research Institute at Baycrest Centre, University of Toronto, Toronto, Canada.
  • McIntosh AR; Rotman Research Institute at Baycrest Centre, University of Toronto, Toronto, Canada.
Cereb Cortex ; 27(3): 1748-1757, 2017 03 01.
Article em En | MEDLINE | ID: mdl-26656723
Adaptation learning is crucial to maintain precise motor control in face of environmental perturbations. Although much progress has been made in understanding the psychophysics and neurophysiology of sensorimotor adaptation (SA), the time course of memory consolidation remains elusive. The lack of a reproducible gradient of memory resistance using protocols of retrograde interference has even led to the proposal that memories produced through SA do not consolidate. Here, we pursued an alternative approach using resting-state fMRI to track changes in functional connectivity (FC) induced by learning. Given that consolidation leads to long-term memory, we hypothesized that a change in FC that predicted long-term memory but not short-term memory would provide indirect evidence for memory stabilization. Six scans were acquired before, 15 min, 1, 3, 5.5, and 24 h after training on a center-out task under veridical or distorted visual feedback. The experimental group showed an increment in FC of a network including motor, premotor, posterior parietal cortex, cerebellum, and putamen that peaked at 5.5 h. Crucially, the strengthening of this network correlated positively with long-term retention but negatively with short-term retention. Our work provides evidence, suggesting that adaptation memories stabilize within a 6-h window, and points to different mechanisms subserving short- and long-term memory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Percepção Visual / Encéfalo / Adaptação Fisiológica / Retroalimentação Sensorial / Memória / Atividade Motora Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Percepção Visual / Encéfalo / Adaptação Fisiológica / Retroalimentação Sensorial / Memória / Atividade Motora Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos