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Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with orexin-A.
Gac, L; Butterick, T A; Duffy, C M; Teske, J A; Perez-Leighton, C E.
Afiliação
  • Gac L; Center for Integrative Medicine and Innovative Science, Facultad de Medicina, Universidad Andres Bello, Santiago, Region Metropolitana, Chile.
  • Butterick TA; Minneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA.
  • Duffy CM; Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA.
  • Teske JA; Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA; Minneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA.
  • Perez-Leighton CE; Center for Integrative Medicine and Innovative Science, Facultad de Medicina, Universidad Andres Bello, Santiago, Region Metropolitana, Chile; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA. Electronic address: claudio.perez@unab.cl.
Peptides ; 76: 14-8, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26654796
Food intake and physical activity are regulated by multiple neuropeptides, including orexin and dynorphin (DYN). Orexin-A (OXA) is one of two orexin peptides with robust roles in regulation of food intake and spontaneous physical activity (SPA). DYN collectively refers to several peptides, some of which act through opioid receptors (opioid DYN) and some whose biological effects are not mediated by opioid receptors (non-opioid DYN). While opioid DYN is known to increase food intake, the effects of non-opioid DYN peptides on food intake and SPA are unknown. Neurons that co-express and release OXA and DYN are located within the lateral hypothalamus. Limited evidence suggests that OXA and opioid DYN peptides can interact to modulate some aspects of behaviors classically related to orexin peptide function. The paraventricular hypothalamic nucleus (PVN) is a brain area where OXA and DYN peptides might interact to modulate food intake and SPA. We demonstrate that injection of des-Tyr-dynorphin (DYN-A(2-17), a non opioid DYN peptide) into the PVN increases food intake and SPA in adult mice. Co-injection of DYN-A(2-17) and OXA in the PVN further increases food intake compared to DYN-A(2-17) or OXA alone. This is the first report describing the effects of non-opioid DYN-A(2-17) on food intake and SPA, and suggests that DYN-A(2-17) interacts with OXA in the PVN to modulate food intake. Our data suggest a novel function for non-opioid DYN-A(2-17) on food intake, supporting the concept that some behavioral effects of the orexin neurons result from combined actions of the orexin and DYN peptides.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Dinorfinas / Orexinas Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Dinorfinas / Orexinas Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos