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Chikungunya Virus Sequences Across the First Epidemic in Nicaragua, 2014-2015.
Wang, Chunling; Saborio, Saira; Gresh, Lionel; Eswarappa, Meghana; Wu, Diane; Fire, Andrew; Parameswaran, Poornima; Balmaseda, Angel; Harris, Eva.
Afiliação
  • Wang C; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Saborio S; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Gresh L; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Eswarappa M; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Wu D; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Fire A; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Parameswaran P; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Balmaseda A; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
  • Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragu
Am J Trop Med Hyg ; 94(2): 400-3, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26643533
Chikungunya is caused by the mosquito-borne arthrogenic alphavirus, chikungunya virus (CHIKV). Chikungunya was introduced into the Americas in late 2013 and Nicaragua in mid-2014. Here, we sequenced five imported and 30 autochthonous Nicaraguan CHIKV from cases identified in the first epidemic in the country between August 2014 and April 2015. One full-length and two partial genomic sequences were obtained by deep sequencing; Sanger methodology yielded 33 E1 sequences from five imported and 28 autochthonous cases. Phylogenetic analysis indicates that Nicaraguan CHIKV all belonged to the Asian genotype, Caribbean clade. Moreover, E1 gene sequences revealed accumulation of mutations in later months of the epidemic, including four silent mutations in 11 autochthonous cases and three non-synonymous mutations in three autochthonous cases. No mutations contributing to increased transmissibility by Aedes albopictus were identified in the E1 gene. This represents the most comprehensive set of CHIKV sequences available from the Americas to date.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Epidemias / Febre de Chikungunya Tipo de estudo: Screening_studies Limite: Humans País/Região como assunto: America central / Nicaragua Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Epidemias / Febre de Chikungunya Tipo de estudo: Screening_studies Limite: Humans País/Região como assunto: America central / Nicaragua Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos