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Role and New Insights of Pirfenidone in Fibrotic Diseases.
Lopez-de la Mora, David Alejandro; Sanchez-Roque, Cibeles; Montoya-Buelna, Margarita; Sanchez-Enriquez, Sergio; Lucano-Landeros, Silvia; Macias-Barragan, Jose; Armendariz-Borunda, Juan.
Afiliação
  • Lopez-de la Mora DA; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
  • Sanchez-Roque C; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
  • Montoya-Buelna M; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
  • Sanchez-Enriquez S; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
  • Lucano-Landeros S; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
  • Macias-Barragan J; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico. ; 2. Departamento de Ciencias de la Salud, CUValles, University of Guadalajara, Guadalajara - Ameca km. 45.5, Ameca (46600
  • Armendariz-Borunda J; 1. Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Sierra Mojada St. 950, Guadalajara (44280), Mexico.
Int J Med Sci ; 12(11): 840-7, 2015.
Article em En | MEDLINE | ID: mdl-26640402
Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-ß1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs. Basic and clinical evidence suggests that PFD may safely slow or inhibit the progressive fibrosis swelling after tissue injuries. Furthermore, a number of evidence suggests that this molecule will have positive effects in the treatment of other inflammatory diseases. This review contains current research in which PFD has been used as the treatment of several diseases, and focus mainly in the outcomes related to improve inflammation and fibrogenesis. Therefore, the main goal of this review is to focus on the novel findings of PFD efficacy rather than deepen in the chemical aspects of the molecule.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Fibrose / Anti-Inflamatórios não Esteroides Limite: Animals / Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Fibrose / Anti-Inflamatórios não Esteroides Limite: Animals / Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Austrália