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Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial.
Silveira, Fábio Coelho Alves; Pinto, Flávia Cristina Morone; Caldas Neto, Sílvio da Silva; Leal, Mariana de Carvalho; Cesário, Jéssica; Aguiar, José Lamartine de Andrade.
Afiliação
  • Silveira FC; Graduate Program in Surgery, Department of Surgery, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil. Electronic address: fcasil@ig.com.br.
  • Pinto FC; Nucleus of Experimental Surgery, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
  • Caldas Neto Sda S; Service of Otolaryngology, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
  • Leal Mde C; Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
  • Cesário J; Medical Course, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
  • Aguiar JL; Graduate Program in Surgery, Department of Surgery, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
Braz J Otorhinolaryngol ; 82(2): 203-8, 2016.
Article em En | MEDLINE | ID: mdl-26631330
INTRODUCTION: Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxicity. OBJECTIVES: To investigate the effect on healing of direct application of a bacterial cellulose graft on the tympanic membrane compared to the conventional approach with autologous fascia. METHODS: Randomized controlled trial. Forty patients with tympanic membrane perforations secondary to chronic otitis media were included, and were randomly assigned to an experimental group (20), treated with a bacterial cellulose graft (BC) and control group (20), treated with autologous temporal fascia (fascia). We evaluated the surgical time, hospital stay, time of epithelialization and the rate of tympanic perforation closure. Hospital costs were compared. The statistical significance level accepted was established at p<0.05. RESULTS: The closure of perforations was similar in both groups. The average operation time in the fascia group was 76.50 min versus 14.06 min bacterial cellulose in the group (p=0.0001). The hospital cost by the Brazilian public health system was R$ 600.00 for the bacterial cellulose group, and R$ 7778.00 for the fascia group (p=0.0001). CONCLUSION: Bacterial cellulose grafts promoted the closure of the tympanic membrane perforations, and were demonstrated to be innovative, effective, safe, minimally invasive, efficacious and to have a very low cost.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Celulose / Perfuração da Membrana Timpânica Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Celulose / Perfuração da Membrana Timpânica Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil