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Liposome-Loaded Cell Backpacks.
Polak, Roberta; Lim, Rosanna M; Beppu, Marisa M; Pitombo, Ronaldo N M; Cohen, Robert E; Rubner, Michael F.
Afiliação
  • Polak R; School of Pharmaceutical Sciences, University of Sao Paulo, USP Sao Paulo, SP, 05508-900, Brazil.
  • Lim RM; Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, M,A, 02139, USA.
  • Beppu MM; Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, 02139, USA.
  • Pitombo RN; School of Chemical Engineering, University of Campinas, UNICAMP, Campinas, SP, 13083-852, Brazil.
  • Cohen RE; School of Pharmaceutical Sciences, University of Sao Paulo, USP Sao Paulo, SP, 05508-900, Brazil.
  • Rubner MF; Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, 02139, USA.
Adv Healthc Mater ; 4(18): 2832-41, 2015 Dec 30.
Article em En | MEDLINE | ID: mdl-26616471
Cell backpacks, or micron-scale patches of a few hundred nanometers in thickness fabricated by layer-by-layer (LbL) assembly, are potentially useful vehicles for targeted drug delivery on the cellular level. In this work, echogenic liposomes (ELIPs) containing the anticancer drug doxorubicin (DOX) are embedded into backpacks through electrostatic interactions and LbL assembly. Poly(allylamine hydrochloride)/poly(acrylic acid) (PAH/PAA)n , and poly(diallyldimethylammonium chloride)/poly(styrene sulfonate) (PDAC/SPS)n film systems show the greatest ELIP incorporation of the films studied while maintaining the structural integrity of the vesicles. The use of ELIPs for drug encapsulation into backpacks facilitates up to three times greater DOX loading compared to backpacks without ELIPs. Cytotoxicity studies reveal that monocyte backpack conjugates remain viable even after 72 h, demonstrating promise as drug delivery vehicles. Because artificial vesicles can load many different types of drugs, ELIP containing backpacks offer a unique versatility for broadening the range of possible applications for cell backpacks.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Lipossomos Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Lipossomos Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha