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Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function.
Pereira, Bruna L B; Arruda, Fernanda C O; Reis, Patrícia P; Felix, Tainara F; Santos, Priscila P; Rafacho, Bruna P; Gonçalves, Andrea F; Claro, Renan T; Azevedo, Paula S; Polegato, Bertha F; Okoshi, Katashi; Fernandes, Ana A H; Paiva, Sergio A R; Zornoff, Leonardo A M; Minicucci, Marcos F.
Afiliação
  • Pereira BL; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. bruh_leticia@hotmail.com.
  • Arruda FC; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. fer_nanda893@hotmail.com.
  • Reis PP; Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. preis@fmb.unesp.br.
  • Felix TF; Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. felix.tainara@gmail.com.
  • Santos PP; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. priscilaportugal@fait.edu.br.
  • Rafacho BP; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. brunapaola@gmail.com.
  • Gonçalves AF; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. andreafgoncalves@gmail.com.
  • Claro RT; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. renan_turini@hotmail.com.
  • Azevedo PS; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. paulasa@fmb.unesp.br.
  • Polegato BF; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. berthafurlan@fmb.unesp.br.
  • Okoshi K; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. katashi@fmb.unesp.br.
  • Fernandes AA; Chemistry and Biochemistry Department, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. angelica@ibb.unesp.br.
  • Paiva SA; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. paiva@fmb.unesp.br.
  • Zornoff LA; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. lzornoff@fmb.unesp.br.
  • Minicucci MF; Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil. minicucci@fmb.unesp.br.
Nutrients ; 7(11): 9640-9, 2015 Nov 19.
Article em En | MEDLINE | ID: mdl-26610560
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415-539); T group: 273 (258-297) µm²; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 ± 46.7; T group: 219 ± 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solanum lycopersicum / Estresse Oxidativo / MicroRNAs / Dieta / Coração Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solanum lycopersicum / Estresse Oxidativo / MicroRNAs / Dieta / Coração Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça