Your browser doesn't support javascript.
loading
Evaluation of Biochemical, Genetic and Hematological Biomarkers in a Commercial Catfish Rhamdia quelen Exposed to Diclofenac.
Ghelfi, Ariane; Ribas, João Luiz Coelho; Guiloski, Izonete Cristina; Bettim, Franciele Lima; Piancini, Laércio Dante Stein; Cestari, Marta Margarete; Pereira, Aramis José; Sassaki, Guilherme Lanzi; Silva de Assis, Helena Cristina.
Afiliação
  • Ghelfi A; Ecology and Conservation Program of Post-Graduation, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Ribas JL; Department of Pharmacology, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Guiloski IC; Department of Pharmacology, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Bettim FL; Department of Pharmacology, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Piancini LD; Department of Genetics, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Cestari MM; Department of Genetics, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Pereira AJ; Department of Biochemistry, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Sassaki GL; Department of Biochemistry, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil.
  • Silva de Assis HC; Department of Pharmacology, Federal University of Paraná, PO Box 19031, Curitiba, Paraná, CEP 81.531-990, Brazil. helassis@ufpr.br.
Bull Environ Contam Toxicol ; 96(1): 49-54, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26589900
Juveniles Rhamdia quelen fish species were exposed to diclofenac for 96 h at concentrations of 0.2, 2, and 20 µg/L. Biochemical, genetic, and hematological biomarkers were assessed in the liver, kidney, and blood in order to evaluate the toxic effects. No oxidative stress was observed in liver. In kidney the superoxide dismutase activity increased in all concentrations, suggesting an alteration in the hydrogen peroxide production, but DNA damage and lipid peroxidation were not detected. Diclofenac exposure increased the red blood cells number at concentrations of 0.2 and 2 µg/L, and monocytes and neutrophils at 2 and 20 µg/L, respectively. These results suggest that acute exposure to diclofenac, even at low concentrations, caused hematologic and renal enzymatic alterations in R. quelen.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Peixes-Gato / Diclofenaco / Estresse Oxidativo / Rim Limite: Animals Idioma: En Revista: Bull Environ Contam Toxicol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Peixes-Gato / Diclofenaco / Estresse Oxidativo / Rim Limite: Animals Idioma: En Revista: Bull Environ Contam Toxicol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos