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[Bone mineral density and its association with body composition and metabolic biomarkers of insulin-glucose axis, bone and adipose tissue in women]. / Densidad mineral ósea y su asociación con la composición corporal y biomarcadores metabólicos del eje insulino-glucosa, hueso y tejido adiposo en mujeres.
Nava-González, Edna J; Cerda-Flores, Ricardo M; García-Hernández, Pedro A; Jasso-de la Peña, Gloria A; Bastarrachea, Raul A; Gallegos-Cabriales, Esther C.
Afiliação
  • Nava-González EJ; Centro de Investigación en Nutrición y Salud Pública, Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
  • Cerda-Flores RM; Subdirección de Posgrado e Investigación, Facultad de Enfermería, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
  • García-Hernández PA; Servicio de Endocrinología del Hospital Universitario de Monterrey «Dr. José Eleuterio González¼, Monterrey, N.L., México.
  • Jasso-de la Peña GA; Servicio de Endocrinología del Hospital Universitario de Monterrey «Dr. José Eleuterio González¼, Monterrey, N.L., México.
  • Bastarrachea RA; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Tx., EE.UU.
  • Gallegos-Cabriales EC; Subdirección de Posgrado e Investigación, Facultad de Enfermería, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
Gac Med Mex ; 151(6): 731-40, 2015.
Article em Es | MEDLINE | ID: mdl-26581531
INTRODUCTION: There are few studies integrating the common causes of osteoporosis and obesity (disorders of body composition). A first step is to investigate correlations between their biological phenotypes to determine their common integrative physiology. OBJECTIVE: To correlate the variation of bone mineral density with phenotypes of body composition and biomarkers of bone physiology, insulin-glucose axis, and adipose tissue. METHODS: Cross-sectional study of 75 women (aged 18-45 years). MEASUREMENTS: Body mass index, waist, fat mass, lean mass (dual-energy X-ray absorptiometry), glucose, insulin, osteocalcin, leptin, tumor necrosis factor alpha. STATISTICAL ANALYSIS: multivariate general linear model, SPSS v.22, p<0.05. RESULTS: Age: 32.08±7.33. Bone mineral content multivariate general linear model 1 with two phenotypes excluded (glucose, insulin): osteocalcin (ß=-0.228, p=0.011), lean mass (ß=0.606, p=0.001) and fat mass (ß=1.237, p=0.001) in 62.0%. The bone mineral density multivariate general linear model 2 with three phenotypes excluded (body mass index, glucose, tumor necrosis factor alpha): insulin (ß=0.250, p=0.024), osteocalcin (ß=-0.362, p=0.001), lean mass (ß=0.512, p=0.001) and fat mass (ß=0.701, p=0.001) in 46.3%. CONCLUSIONS: Results show that body composition with an increased lean mass is beneficial to bone. This study reaffirms the importance of performing regular exercise to prevent muscle loss.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Densidade Óssea / Tecido Adiposo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2015 Tipo de documento: Article País de publicação: México
Buscar no Google
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Densidade Óssea / Tecido Adiposo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2015 Tipo de documento: Article País de publicação: México