[Role of Serotonin Transporter Gene in Eating Disorders]. / El papel del gen del transportador de serotonina en los trastornos de la conducta alimentaria.
Rev Colomb Psiquiatr
; 43(4): 218-24, 2014.
Article
em Es
| MEDLINE
| ID: mdl-26574079
BACKGROUND: The serotoninergic system has been implicated in mood and appetite regulation, and the serotonin transporter gene (SLC6A4) is a commonly studied candidate gene for eating disorders. However, most studies have focused on a single polymorphism (5-HTTLPR) in SLC6A4. OBJECTIVE: We present the studies published on the association between eating disorders (ED) and 5-HTTLPR polymorphism in anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not otherwise specified (EDNOS). METHOD: Search of databases: MEDLINE, ISI, and PubMed for SLC6A4 and ED. CONCLUSIONS: From a review of 37 original articles, it was suggested that carriers of S allele is a risk factor for eating disorders, especially for AN. However, BN did not show any association. Also, BMI, impulsivity, anxiety, depression, and age of onset have been associated with S allele in ED patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
Es
Revista:
Rev Colomb Psiquiatr
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Colômbia