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New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression.
Valverde-Villegas, Jacqueline María; Matte, Maria Cristina Cotta; de Medeiros, Rúbia Marília; Chies, José Artur Bogo.
Afiliação
  • Valverde-Villegas JM; Immunogenetics Laboratory, Genetics Department, Genetics and Molecular Biology Post-Graduate Program, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, Prédio 43323, 91501-970 Porto Alegre, RS, Brazil.
  • Matte MC; Immunogenetics Laboratory, Genetics Department, Genetics and Molecular Biology Post-Graduate Program, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, Prédio 43323, 91501-970 Porto Alegre, RS, Brazil.
  • de Medeiros RM; Immunogenetics Laboratory, Genetics Department, Genetics and Molecular Biology Post-Graduate Program, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, Prédio 43323, 91501-970 Porto Alegre, RS, Brazil.
  • Chies JA; Immunogenetics Laboratory, Genetics Department, Genetics and Molecular Biology Post-Graduate Program, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, Prédio 43323, 91501-970 Porto Alegre, RS, Brazil.
J Immunol Res ; 2015: 647916, 2015.
Article em En | MEDLINE | ID: mdl-26568963
Treg and Th17 cell subsets are characterized by the expression of specific transcriptional factors and chemokine receptor as well as by secretion of specific cytokine and chemokines. These subsets are important to the differentiation, expansion, homing capacity, and recruitment of several different immune cell populations to the site of infection. Whereas Treg cells maintain self-tolerance and control the activation and expansion of autoreactive CD4(+) T effector cells through an anti-inflammatory response, Th17 cells, in an exacerbated unregulated proinflammatory response, can promote autoimmunity. Despite such apparently opposite functions, Th17 and Treg cells share common characteristics, and their differentiation pathways are interconnected. Recent studies have revealed quite intricate relations between Treg and Th17 cells in HIV infection and progression to AIDS. Considering Treg cells, different subsets were already investigated in the context of HIV infection, indicating a fluctuation in the total number and frequency throughout the disease course. This review focuses on the recent findings regarding the role of regulatory T and Th17 cells in the context of HIV infection, highlighting the importance of the balance between these two subsets on disease progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV / Linfócitos T Reguladores / Células Th17 Limite: Animals / Humans Idioma: En Revista: J Immunol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Egito
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV / Linfócitos T Reguladores / Células Th17 Limite: Animals / Humans Idioma: En Revista: J Immunol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Egito