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Calibration Model for Apnea-Hypopnea Indices: Impact of Alternative Criteria for Hypopneas.
Ho, Vu; Crainiceanu, Ciprian M; Punjabi, Naresh M; Redline, Susan; Gottlieb, Daniel J.
Afiliação
  • Ho V; Department of Medicine, Division of Sleep Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Crainiceanu CM; Department of Medicine, The Pulmonary Center, Boston University School of Medicine, Boston, MA.
  • Punjabi NM; Veterans Affairs Boston Healthcare System, West Roxbury, MA.
  • Redline S; Department of Biostatistics, Johns Hopkins University.
  • Gottlieb DJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Sleep ; 38(12): 1887-92, 2015 Dec 01.
Article em En | MEDLINE | ID: mdl-26564122
STUDY OBJECTIVE: To characterize the association among apnea-hypopnea indices (AHIs) determined using three common metrics for defining hypopnea, and to develop a model to calibrate between these AHIs. DESIGN: Cross-sectional analysis of Sleep Heart Health Study Data. SETTING: Community-based. PARTICIPANTS: There were 6,441 men and women age 40 y or older. MEASUREMENT AND RESULTS: Three separate AHIs have been calculated, using all apneas (defined as a decrease in airflow greater than 90% from baseline for ≥ 10 sec) plus hypopneas (defined as a decrease in airflow or chest wall or abdominal excursion greater than 30% from baseline, but not meeting apnea definitions) associated with either: (1) a 4% or greater fall in oxyhemoglobin saturation-AHI4; (2) a 3% or greater fall in oxyhemoglobin saturation-AHI3; or (3) a 3% or greater fall in oxyhemoglobin saturation or an event-related arousal-AHI3a. Median values were 5.4, 9.7, and 13.4 for AHI4, AHI3, and AHI3a, respectively (P < 0.0001). Penalized spline regression models were used to compare AHI values across the three metrics and to calculate prediction intervals. Comparison of regression models demonstrates divergence in AHI scores among the three methods at low AHI values and gradual convergence at higher levels of AHI. CONCLUSIONS: The three methods of scoring hypopneas yielded significantly different estimates of the apnea-hypopnea index (AHI), although the relative difference is reduced in severe disease. The regression models presented will enable clinicians and researchers to more appropriately compare AHI values obtained using differing metrics for hypopnea.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes da Apneia do Sono Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes da Apneia do Sono Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos