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Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease.
Bianco, Otávio Augusto Fernandes Marques; Manzine, Patrícia Regina; Nascimento, Carla Manuela Crispim; Vale, Francisco Assis Carvalho; Pavarini, Sofia Cristina Iost; Cominetti, Márcia Regina.
Afiliação
  • Bianco OA; Department of Gerontology,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
  • Manzine PR; Department of Gerontology,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
  • Nascimento CM; Department of Gerontology,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
  • Vale FA; Department of Medicine,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
  • Pavarini SC; Department of Gerontology,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
  • Cominetti MR; Department of Gerontology,Federal University of São Carlos (UFSCar),São Carlos,SP,Brazil.
Int Psychogeriatr ; 28(6): 939-44, 2016 06.
Article em En | MEDLINE | ID: mdl-26555131
BACKGROUND: Studies have demonstrated a decreased platelet ADAM10 expression in patients with Alzheimer's Disease (AD), classifying this protein as a blood-based AD biomarker. About 50% of the patients with AD are diagnosed with depression, which is commonly treated with tricyclic and tetracyclic antidepressants, monoaminoxidade (MAO) inhibitors and, more preferably, with selective serotonin reuptake inhibitors (SSRIs). Considering that a large proportion of patients with AD takes antidepressant medications during the course of the disease we investigated the influence of this medication on the expression of platelet ADAM10, which is considered the main α-secretase preventing beta-amyloid (ßA) formation. METHODS: Blood was collected for protein extraction from platelets. ADAM10 was analyzed by using western blotting and reactive bands were measured using ß-actin as endogenous control. RESULTS: Platelet ADAM10 protein expression in patients with AD was positively influenced by serotoninergic medication. CONCLUSION: More studies on the positive effects of serotonergic antidepressants on ADAM10 platelet expression should be performed in order to understand its biological mechanisms and to verify whether these effects are reflected in the central nervous system. This work represents an important advance for the study of AD biomarkers, as well as for more effective pharmacological treatment of patients with AD and associated depression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Inibidores Seletivos de Recaptação de Serotonina / Doença de Alzheimer / Proteína ADAM10 / Antidepressivos Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int Psychogeriatr Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Inibidores Seletivos de Recaptação de Serotonina / Doença de Alzheimer / Proteína ADAM10 / Antidepressivos Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int Psychogeriatr Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido