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Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats.
Botelho, Marco A; Barros, Gisele; Queiroz, Dinalva B; Carvalho, Celso Felício; Gouvea, Julia; Patrus, Lia; Bannet, Mariane; Patrus, Danile; Rego, Amália; Silva, Ivaldo; Campus, Guglielmo; Araújo-Filho, Irami.
Afiliação
  • Botelho MA; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Barros G; Department of Surgery, Microsurgery and Medicine Sciences, School of Dentistry, University of Sassari, Sassari, Italy.
  • Queiroz DB; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Carvalho CF; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Gouvea J; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Patrus L; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Bannet M; School of Health, University Anhembi-Morumbi, Sao Paulo, SP, Brazil.
  • Patrus D; School of Health, University Anhembi-Morumbi, Sao Paulo, SP, Brazil.
  • Rego A; School of Health, University Anhembi-Morumbi, Sao Paulo, SP, Brazil.
  • Silva I; Post Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
  • Campus G; Departament of Gynecology, Federal University of São Paulo, Sao Paulo, SP, Brazil.
  • Araújo-Filho I; Department of Surgery, Microsurgery and Medicine Sciences, School of Dentistry, University of Sassari, Sassari, Italy.
Phytother Res ; 30(1): 152-9, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26553130
Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as 'Alecrim-pimenta'. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2 mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae. Animals were treated with TG, immediately after APD induction. Saline-based gel was utilized as negative control and diethylammonium diclofenac gel 10 mg/g was used as positive control. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p < 0.05). The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Timol / Nanotecnologia / Lippia / Fitoterapia Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Timol / Nanotecnologia / Lippia / Fitoterapia Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido