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Toxicological analysis and anti-inflammatory effects of essential oil from Piper vicosanum leaves.
Hoff Brait, Débora Regina; Mattos Vaz, Márcia Soares; da Silva Arrigo, Jucicléia; Borges de Carvalho, Luciana Noia; Souza de Araújo, Flávio Henrique; Vani, Juliana Miron; da Silva Mota, Jonas; Cardoso, Claudia Andrea Lima; Oliveira, Rodrigo Juliano; Negrão, Fábio Juliano; Kassuya, Cândida Aparecida Leite; Arena, Arielle Cristina.
Afiliação
  • Hoff Brait DR; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Mattos Vaz MS; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • da Silva Arrigo J; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Borges de Carvalho LN; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Souza de Araújo FH; Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Vani JM; Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • da Silva Mota J; Mato Grosso do Sul State University (UEMS), Dourados, MS, Brazil.
  • Cardoso CA; Mato Grosso do Sul State University (UEMS), Dourados, MS, Brazil.
  • Oliveira RJ; Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Negrão FJ; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Kassuya CA; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Arena AC; School of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil; Department of Morphology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, SP, Brazil. Electronic address: ariellearena@ibb.unesp.br.
Regul Toxicol Pharmacol ; 73(3): 699-705, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26545326
This study assessed the anti-inflammatory effects of the essential oil from Piper vicosanum leaves (OPV) and evaluated the toxicological potential of this oil through acute toxicity, genotoxicity and mutagenicity tests. The acute toxicity of OPV was evaluated following oral administration to female rats at a single dose of 2 g/kg b.w. To evaluate the genotoxic and mutagenic potential, male mice were divided into five groups: I: negative control; II: positive control; III: 500 mg/kg of OPV; IV: 1000 mg/kg of OPV; V: 2000 mg/kg of OPV. The anti-inflammatory activity of OPV was evaluated in carrageenan-induced pleurisy and paw edema models in rats. No signs of acute toxicity were observed, indicating that the LD50 of this oil is greater than 2000 mg/kg. In the comet assay, OPV did not increase the frequency or rate of DNA damage in groups treated with any of the doses assessed compared to that in the negative control group. In the micronucleus test, the animals treated did not exhibit any cytotoxic or genotoxic changes in peripheral blood erythrocytes. OPV (100 and 300 mg/kg) significantly reduced edema formation and inhibited leukocyte migration analyzed in the carrageenan-induced edema and pleurisy models. These results show that OPV has anti-inflammatory potential without causing acute toxicity or genotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pleurisia / Óleos de Plantas / Óleos Voláteis / Extratos Vegetais / Piper / Edema / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pleurisia / Óleos de Plantas / Óleos Voláteis / Extratos Vegetais / Piper / Edema / Anti-Inflamatórios Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda