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Effects of beta 2 adrenergic agonists on axonal injury and mitochondrial metabolism in experimental autoimmune encephalomyelitis rats.
Zhang, Z W; Qin, X Y; Che, F Y; Xie, G; Shen, L; Bai, Y Y.
Afiliação
  • Zhang ZW; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China zhangzuowen201501@163.com.
  • Qin XY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Che FY; Department of Neurology, Jiangjin Central Hospital, Chongqing, China.
  • Xie G; Department of Neurology, Jiangjin Central Hospital, Chongqing, China.
  • Shen L; Department of Neurology, Jiangjin Central Hospital, Chongqing, China.
  • Bai YY; Department of Neurology, Jiangjin Central Hospital, Chongqing, China.
Genet Mol Res ; 14(4): 13572-81, 2015 Oct 28.
Article em En | MEDLINE | ID: mdl-26535670
The primary aims of this study were to investigate mitochondrial metabolism during experimental allergic encephalomyelitis (EAE) animal model axonal injury and to determine the correlation among neurological function scores, pathological changes, and the activities of the BB isoenzyme of creatine kinase (CK-BB), catalase (CAT), and calpain in the brain tissues of EAE rats. Another goal was to preliminarily define the mechanism of mitochondrial metabolism resulting from the effect of beta 2 adrenergic agonists in the process of EAE animal model axonal damage. EAE was induced in specific pathogen free Wistar rats by guinea pig spinal cord homogenate, complete Freund's adjuvant, and pertussis vaccine. We recorded the behavioral change in EAE rats, detected pathological changes in central nervous tissue, and observed the changes of the CK-BB, CAT, and calpain in the EAE rat brain and spinal cord. The results indicated that the average neurologic function score increased in the EAE group compared to that of the controls (P < 0.01). In addition, CAT and CK-BB activities significantly decreased and the calpain activity significantly increased compared with those of the control group (P < 0.05). The decrease of the activity of central nervous CK-BB and CAT content, as well as the increase of calpain activity at the highest time point were considered to be the consequences of EAE. Furthermore, the results revealed that use of salbutamol could alleviate disease symptoms and reduce the recurrence of the EAE disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Axônios / Encefalomielite Autoimune Experimental / Agonistas de Receptores Adrenérgicos beta 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Axônios / Encefalomielite Autoimune Experimental / Agonistas de Receptores Adrenérgicos beta 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil