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Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis.
Jin, X F; Wang, D L; Zhou, Y; Xiong, H.
Afiliação
  • Jin XF; Shandong University Hospital of Traditional Chinese Medicine, Jinan, China.
  • Wang DL; Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Zhou Y; Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Xiong H; Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Genet Mol Res ; 14(4): 13076-83, 2015 Oct 26.
Article em En | MEDLINE | ID: mdl-26535620
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed- or random-effect models. A total of seven case-control studies containing 2025 patients and 2174 controls were enrolled into this meta-analysis. In combined analysis, the results showed no significant association between the IL6 -174 G/C polymorphism and ischemic stroke risk in the overall population (GG vs CC: OR = 1.22, 95%CI = 0.50-3.01; TT vs TC: OR = 0.97, 95%CI = 0.81-1.15; dominant: OR = 0.98, 95%CI = 0.70-1.38; or recessive: OR = 1.24, 95%CI = 0.57-2.70) models. In the subgroup analysis by race, no significant associations between the -174 G/C polymorphism in the IL6 gene and ischemic stroke risk were found in Caucasians or Asians. No publication bias was found in the present study (all P > 0.05). Overall, the meta-analysis results suggested that the IL6 -174 G/C polymorphism was not associated with an increased risk of ischemic stroke. Further large and well-designed studies are needed to confirm this conclusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Interleucina-6 / Predisposição Genética para Doença / Acidente Vascular Cerebral / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Interleucina-6 / Predisposição Genética para Doença / Acidente Vascular Cerebral / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil