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Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features.
Silva, Helen Aguiar Lemes da; Lima, Gabriel Silva de; Boité, Mariana Côrtes; Porrozzi, Renato; Hueb, Marcia; Damazo, Amilcar Sabino.
Afiliação
  • Silva HA; Pós-Graduação em Ciências da Saúde, Laboratório de Histologia, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
  • Lima GS; Laboratório de Histologia, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
  • Boité MC; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Porrozzi R; Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Hueb M; Hospital Universitário Julio Müller, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
  • Damazo AS; Pós-Graduação em Ciências da Saúde, Laboratório de Histologia, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
Rev Soc Bras Med Trop ; 48(5): 560-7, 2015.
Article em En | MEDLINE | ID: mdl-26516965
INTRODUCTION: The aim of this study was quantify annexin A1 expression in macrophages and cluster of differentiation 4 (CD4) + and cluster of differentiation 8 (CD8)+ T cells from the skin of patients with cutaneous leishmaniasis (n=55) and correlate with histopathological aspects. METHODS: Infecting species were identified by polymerase chain reaction-restriction fragment length polymorphism, and expression of annexin A1 was analyzed by immunofluorescence. RESULTS: All patients (n = 55) were infected with Leishmania braziliensis . Annexin A1 was expressed more abundantly in CD163 + macrophages in infected skin (p < 0.0001) than in uninfected skin. In addition, macrophages in necrotic exudative reaction lesions expressed annexin A1 at higher levels than those observed in granulomatous (p < 0.01) and cellular lesions p < 0.05). This difference might be due to the need to clear both parasites and necrotic tissue from necrotic lesions. CD4 + cells in cellular lesions expressed annexin A1 more abundantly than did those in necrotic (p < 0.05) and granulomatous lesions (p < 0.01). Expression in CD8 + T cells followed the same trend. These differences might be due to the pervasiveness of lymphohistiocytic and plasmacytic infiltrate in cellular lesions. CONCLUSIONS: Annexin A1 is differentially expressed in CD163 + macrophages and T cells depending on the histopathological features of Leishmania -infected skin, which might affect cell activation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose Cutânea / Anexina A1 / Leishmania Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmaniose Cutânea / Anexina A1 / Leishmania Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil