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Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis.
Beppler, Jaqueline; Koehler-Santos, Patrícia; Pasqualim, Gabriela; Matte, Ursula; Alho, Clarice Sampaio; Dias, Fernando Suparregui; Kowalski, Thayne Woycinck; Velasco, Irineu Tadeu; Monteiro, Renato C; Pinheiro da Silva, Fabiano.
Afiliação
  • Beppler J; Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
  • Koehler-Santos P; Proteins and Molecular Analysis Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Pasqualim G; Gene Therapy Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Matte U; Postgraduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Alho CS; Gene Therapy Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Dias FS; School of Biosciences and Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Kowalski TW; School of Biosciences and Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Velasco IT; Postgraduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Monteiro RC; Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
  • Pinheiro da Silva F; Inserm Unit 1149 and ERL Cnrs 8252, Center for Research on Inflammation, University Paris Diderot, Paris, France.
Inflammation ; 39(2): 518-25, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26490967
Sepsis is a devastating disease that can affect humans at any time between neonates and the elderly and is associated with mortality rates that range from 30 to 80%. Despite intensive efforts, its treatment has remained the same over the last few decades. Fc receptors regulate multiple immune responses and have been investigated in diverse complex diseases. FcγRIIA (CD32A) is an immunoreceptor, tyrosine-based activation motif-bearing receptor that binds immunoglobulin G and C-reactive protein, important opsonins in host defense. We conducted a study of 702 patients (184 healthy individuals, 171 non-infected critically ill patients, and 347 sepsis patients) to investigate if genetic polymorphisms in the CD32A coding region affect the risk of septic shock. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene. We found that allele G, associated with the R131 genotype, was significantly more frequent in septic patients than in the other groups (p = 0.05). Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de IgG / Sepse / Predisposição Genética para Doença Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Inflammation Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de IgG / Sepse / Predisposição Genética para Doença Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Inflammation Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos