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A Cost-Effectiveness Analysis of a Pilot Neonatal Screening Program for Sickle Cell Anemia in the Republic of Angola.
McGann, Patrick T; Grosse, Scott D; Santos, Brigida; de Oliveira, Vysolela; Bernardino, Luis; Kassebaum, Nicholas J; Ware, Russell E; Airewele, Gladstone E.
Afiliação
  • McGann PT; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Grosse SD; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.
  • Santos B; Centro de Apoio ao Doente Anémico, Hospital Pediátrico David Bernardino, Luanda, Angola.
  • de Oliveira V; Centro de Apoio ao Doente Anémico, Hospital Pediátrico David Bernardino, Luanda, Angola.
  • Bernardino L; Centro de Apoio ao Doente Anémico, Hospital Pediátrico David Bernardino, Luanda, Angola.
  • Kassebaum NJ; Institute for Health Metrics and Evaluation, Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital and University of Washington, Seattle, WA.
  • Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Airewele GE; Texas Children's Cancer and Hematology Centers and Department of Pediatrics, Baylor College of Medicine, Houston, TX. Electronic address: gairewele@txch.org.
J Pediatr ; 167(6): 1314-9, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26477868
OBJECTIVE: To assess the cost-effectiveness of a pilot newborn screening (NBS) and treatment program for sickle cell anemia (SCA) in Luanda, Angola. STUDY DESIGN: In July 2011, a pilot NBS and treatment program was implemented in Luanda, Angola. Infants identified with SCA were enrolled in a specialized SCA clinic in which they received preventive care and sickle cell education. In this analysis, the World Health Organization (WHO) and generalized cost-effectiveness analysis methods were used to estimate gross intervention costs of the NBS and treatment program. To determine healthy life-years (HLYs) gained by screening and treatment, we assumed NBS reduced mortality to that of the Angolan population during the first 5 years based upon WHO and Global Burden of Diseases Study 2010 estimates, but provided no significant survival benefit for children who survive through age 5 years. A secondary sensitivity analysis with more conservative estimates of mortality benefits also was performed. The costs of downstream medical costs, including acute care, were not included. RESULTS: Based upon the costs of screening 36,453 infants and treating the 236 infants with SCA followed after NBS in the pilot project, NBS and treatment program is projected to result in the gain of 452-1105 HLYs, depending upon the discounting rate and survival assumptions used. The corresponding estimated cost per HLY gained is $1380-$3565, less than the gross domestic product per capita in Angola. CONCLUSIONS: These data demonstrate that NBS and treatment for SCA appear to be highly cost-effective across all scenarios for Angola by the WHO criteria.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triagem Neonatal / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Evaluation_studies / Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triagem Neonatal / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Evaluation_studies / Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Limite: Female / Humans / Infant / Male / Newborn País/Região como assunto: Africa Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos