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Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease.
Geng, G Y; Liu, H L; Zhao, Y J; Wu, L; Mao, L; Ba, N.
Afiliação
  • Geng GY; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
  • Liu HL; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
  • Zhao YJ; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
  • Wu L; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
  • Mao L; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
  • Ba N; Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
Genet Mol Res ; 14(3): 11488-94, 2015 Sep 25.
Article em En | MEDLINE | ID: mdl-26436389
A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People's Hospital between May 2012 and May 2014. The IL-17A rs2275913 and IL-17F rs763780 genes were genotyped by polymerase chain reaction combined with a restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis revealed that individuals with the AA genotype of rs2275913 were associated with increased risk of CAD, compared to those with the GG genotype in a codominant model [adjusted odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.10-3.53]. On the other hand, the AA genotype of rs2275913 was correlated with moderately increased risk of CAD compared to the GG + GA genotype (adjusted OR = 1.76; 95%CI = 1.02-3.07) in a recessive model. However, no significant differences were observed between polymorphisms at the IL-17F rs763780 locus and CAD risk, in codominant, dominant, and recessive models. In conclusion, the results of our study suggested that the IL-17A rs2275913 polymorphism may affect the development of CAD; however, no significant association was observed between the IL-17F rs763780 polymorphism and risk of CAD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Predisposição Genética para Doença / Interleucina-17 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Predisposição Genética para Doença / Interleucina-17 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil