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A Retrospective Analysis of the Significance of Haemoglobin SS and SC in Disease Outcome in Patients With Sickle Cell Disease and Dengue Fever.
Rankine-Mullings, Angela; Reid, Marvin E; Moo Sang, Michelle; Richards-Dawson, Michelle-Ann; Knight-Madden, Jennifer M.
Afiliação
  • Rankine-Mullings A; Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Mona Kingston 7, Jamaica.
  • Reid ME; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona Kingston 7, Jamaica.
  • Moo Sang M; Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Mona Kingston 7, Jamaica.
  • Richards-Dawson MA; Bustamante Hospital for Children, Arthur Wint Drive, Kingston 5, Jamaica.
  • Knight-Madden JM; Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Mona Kingston 7, Jamaica.
EBioMedicine ; 2(8): 937-41, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26425701
BACKGROUND: Little is known about the significance of haemoglobin genotype in dengue fever severity. This study was undertaken to determine the case fatality ratio and the impact of genotype in patients with sickle cell disease and confirmed dengue fever. METHODS: This retrospective analysis included 40 patients with confirmed dengue and sickle cell disease, during the study period (2010-2012). FINDINGS: There was a significantly higher case fatality ratio, 12.5% among patients with either haemoglobin SC disease or homozygous SS disease when compared to that of the general population 0.41% (p < 0.0001). The unadjusted odds of dying among those with haemoglobin SC disease compared with the group with homozygous SS disease was OR = 4.4 (95% CI 0.6 to 31.7). The predictors of mortality independent of sickle cell disease genotype were haemoglobin concentration at presentation OR = 0.57 (95% CI, 0.35 to 0.94) and the change in haemoglobin concentration from steady state OR = 0.59 (95% CI, 0.37 to 0.94). Adjusting for haemoglobin concentration at presentation increased the risk of death for the SC genotype relative to SS genotype OR = 13.4 (95% CI 1.1 to 160.3). INTERPRETATION: The risk of fatal dengue may be higher among patients with a relatively mild genotype (haemoglobin SC).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Dengue / Heterozigoto / Homozigoto / Anemia Falciforme Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: EBioMedicine Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Jamaica País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Dengue / Heterozigoto / Homozigoto / Anemia Falciforme Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: EBioMedicine Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Jamaica País de publicação: Holanda