Your browser doesn't support javascript.
loading
Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4.
Pértille, F; Zanella, R; Felício, A M; Ledur, M C; Peixoto, J O; Coutinho, L L.
Afiliação
  • Pértille F; Labortório de Biotecnologia Animal, Departamento de Zootecnia, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba, SP, Brasil.
  • Zanella R; Embrapa Suínos e Aves, Concórdia, SC, Brasil.
  • Felício AM; Labortório de Biotecnologia Animal, Departamento de Zootecnia, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba, SP, Brasil.
  • Ledur MC; Embrapa Suínos e Aves, Concórdia, SC, Brasil.
  • Peixoto JO; Embrapa Suínos e Aves, Concórdia, SC, Brasil.
  • Coutinho LL; Labortório de Biotecnologia Animal, Departamento de Zootecnia, Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba, SP, Brasil.
Genet Mol Res ; 14(3): 10717-28, 2015 Sep 09.
Article em En | MEDLINE | ID: mdl-26400301
Genetic selection for production traits has resulted in a rapid improvement in animal performance and development. Previous studies have mapped quantitative trait loci for body weight at 35 and 41 days, and drum and thigh yield, onto chicken chromosome 4. We investigated this region for single nucleotide polymorphisms and their associations with important economic traits. Three positional candidate genes were studied: KLF3 (Krüeppel-like factor 3), SLIT2 (Slit homolog 2), and PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha). Fragment sequencing of these genes was conducted in 11 F1 animals, and one polymorphism in each gene was selected and genotyped in an F2 population (N = 276) and a paternal broiler line TT (N = 840). Associations were identified with growth, carcass, and fat traits in the F2 and the paternal line (P < 0.05). Using single markers in both the F2 and the TT line, KLF3 was associated with weight gain (P < 0.05), PPPARGC1A was associated with liver and wing-parts weights and yields (P < 0.05), and SLIT2 was associated with back yield (P < 0.05) and fat traits (P < 0.05). Using multiple markers, KLF3 lost its significance in both populations, and SLIT2 was associated with feed conversion only in the TT population (P < 0.05). The QTLs mapped in the F2 population could be partly explained by PPARGC1A and SLIT2, which were associated with body weight at 35 and 41 days, respectively, and with drum and thigh yield in the same population. The results of this study indicate the importance of these genes for production traits.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Cromossomos / Polimorfismo de Nucleotídeo Único / Peptídeos e Proteínas de Sinalização Intercelular / Locos de Características Quantitativas / Carne / Proteínas do Tecido Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Cromossomos / Polimorfismo de Nucleotídeo Único / Peptídeos e Proteínas de Sinalização Intercelular / Locos de Características Quantitativas / Carne / Proteínas do Tecido Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil