Your browser doesn't support javascript.
loading
Clinical Usefulness of Serum Krebs von den Lungen-6 for Detecting Chronic Aspiration in Children with Severe Motor and Intellectual Disabilities.
Wakamoto, Hiroyuki; Sano, Nozomi; Yano, Yoshiaki; Sakai, Shinya; Kikuchi, Takanori; Fukuda, Mitsumasa; Morimoto, Takehiko; Ishii, Eiichi.
Afiliação
  • Wakamoto H; Department of Pediatrics, Ehime Rehabilitation Center for Children, Ehime, Japan. Electronic address: wakamoto-hiroyuki@pref.ehime.jp.
  • Sano N; Department of Pediatrics, National Hospital Organization Minami Kyushu Hospital, Kagoshima, Japan.
  • Yano Y; Department of Pediatrics, National Hospital Organization Ehime Medical Center, Ehime, Japan.
  • Sakai S; Department of Radiology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.
  • Kikuchi T; Department of Radiology, Ehime Prefectural Central Hospital, Ehime, Japan.
  • Fukuda M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
  • Morimoto T; Department of Pediatrics, Ehime Rehabilitation Center for Children, Ehime, Japan.
  • Ishii E; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
J Pediatr ; 167(5): 1136-42, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26382626
OBJECTIVE: To determine whether the serum level of Krebs von den Lungen-6 (KL-6), a circulating high-molecular weight glycoprotein and a diagnostic biomarker of interstitial lung diseases, is a clinically useful biomarker for detecting chronic aspiration in children with severe motor and intellectual disabilities (SMIDS). STUDY DESIGN: Children with SMIDS undergoing videofluorography for assessment of dysphagia were prospectively evaluated. Based on the videofluorography results, the participants were classified into aspiration and non-aspiration groups. Age, sex, white blood cell count, and serum levels of C-reactive protein, lactate dehydrogenase, albumin, and KL-6 were compared between the 2 groups. Binary logistic regression was performed to identify factors independently associated with the presence of aspiration. RESULTS: A total of 66 patients participated in this study, 37 who were classified as the aspiration group and 29 as the non-aspiration group. The serum KL-6 level in the aspiration group was significantly higher than that in the non-aspiration group (median, 344 U/mL vs 207 U/mL, P < .01). Logistic regression modeling showed that the number of prescribed antiepileptic drugs (OR, 1.978; 95% CI, 1.217, 3.214; P < .01) and serum KL-6 level (OR, 1.012; 95% CI, 1.005, 1.019; P < .01) were independent predictors of aspiration. CONCLUSIONS: The study demonstrated that the KL-6 level is significantly higher in children with SMIDS who aspirate than in those who do not. KL-6 shows promise as a biomarker for chronic lung disease due to aspiration in these children.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Aspirativa / Mucina-1 / Deficiência Intelectual Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Aspirativa / Mucina-1 / Deficiência Intelectual Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos