Your browser doesn't support javascript.
loading
Echocardiographic Predictors of Worse Outcome After Cardiac Resynchronization Therapy.
Rocha, Eduardo Arrais; Pereira, Francisca Tatiana Moreira; Abreu, José Sebastião; Lima, José Wellington O; Monteiro, Marcelo de Paula M; Rocha Neto, Almino Cavalcante; Quidute, Ana Rosa Pinto; Goés, Camilla Viana A; Rodrigues Sobrinho, Carlos Roberto Martins; Scanavacca, Maurício Ibrahim.
Afiliação
  • Rocha EA; Universidade de São Paulo, São Paulo, SP, Brazil.
  • Pereira FT; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Abreu JS; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Lima JW; Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
  • Monteiro Mde P; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Rocha Neto AC; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Quidute AR; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Goés CV; Universidade de São Paulo, São Paulo, SP, Brazil.
  • Rodrigues Sobrinho CR; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Scanavacca MI; Universidade de São Paulo, São Paulo, SP, Brazil.
Arq Bras Cardiol ; 105(6): 552-9, 2015 Dec.
Article em En, Pt | MEDLINE | ID: mdl-26351981
BACKGROUND: Cardiac resynchronization therapy (CRT) is the recommended treatment by leading global guidelines. However, 30%-40% of selected patients are non-responders. OBJECTIVE: To develop an echocardiographic model to predict cardiac death or transplantation (Tx) 1 year after CRT. METHOD: Observational, prospective study, with the inclusion of 116 patients, aged 64.89 ± 11.18 years, 69.8% male, 68,1% in NYHA FC III and 31,9% in FC IV, 71.55% with left bundle-branch block, and median ejection fraction (EF) of 29%. Evaluations were made in the pre­implantation period and 6-12 months after that, and correlated with cardiac mortality/Tx at the end of follow-up. Cox and logistic regression analyses were performed with ROC and Kaplan-Meier curves. The model was internally validated by bootstrapping. RESULTS: There were 29 (25%) deaths/Tx during follow-up of 34.09 ± 17.9 months. Cardiac mortality/Tx was 16.3%. In the multivariate Cox model, EF < 30%, grade III/IV diastolic dysfunction and grade III mitral regurgitation at 6­12 months were independently related to increased cardiac mortality or Tx, with hazard ratios of 3.1, 4.63 and 7.11, respectively. The area under the ROC curve was 0.78. CONCLUSION: EF lower than 30%, severe diastolic dysfunction and severe mitral regurgitation indicate poor prognosis 1 year after CRT. The combination of two of those variables indicate the need for other treatment options.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Coração / Medição de Risco / Terapia de Ressincronização Cardíaca / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Coração / Medição de Risco / Terapia de Ressincronização Cardíaca / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil