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Protective effects of morphine preconditioning in delayed phase on myocardial ischemia-reperfusion injury in rabbits.
Lu, X-H; Ran, K; Xiao, Y-Y; Yang, D-L; Chang, Y-T; Duan, K-M; Ou, Y-W.
Afiliação
  • Lu XH; Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China.
  • Ran K; Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China.
  • Xiao YY; Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China.
  • Yang DL; Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China.
  • Chang YT; Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China.
  • Duan KM; Department of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, China.
  • Ou YW; Department of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, China.
Genet Mol Res ; 14(3): 8947-54, 2015 Aug 07.
Article em En | MEDLINE | ID: mdl-26345826
The aim of this study was to investigate the protective mechanisms of delayed-phase morphine preconditioning on myocardial ischemia-reperfusion injury. Thirty healthy male New Zealand white rabbits were randomly divided into three groups: a sham operation group (C), ischemia-reperfusion group (I/R), and delayed-phase morphine preconditioning group (M) (N = 10/group). Rabbits in the C group received thoracotomy for 160 min. Rabbits in the I/R group received left artery blockage for 40 min and reperfusion for 120 min. Rabbits in the M group received 1.0 mg/kg intravenous morphine 24 h prior to the identical treatment as the rabbits in the I/R group. In each group, the interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were detected at five time points: 20 min before the left coronary artery blockage (T1), 20 and 40 min after the left coronary artery blockage (T2 and T3, respectively), and 1 and 2 h after the myocardial reperfusion (T4 and T5, respectively). After reperfusion, the infarction size was measured with Evans blue and 2,3,5-triphenyltetrazolium chloride (TTC) staining. Compared with the C group, serum IL-10 and TNF-α concentrations increased in the I/R and M groups; the difference was significant (P < 0.05). When compared with the I/R group, the IL-10 concentrations in the M group were significantly increased (P < 0.05), but the infarction size and TNF-α concentrations were significantly decreased (P < 0.05). These results suggested that delayed-phase morphine preconditioning might achieve myocardial protection through the regulation and balance of inflammatory cytokines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Precondicionamento Isquêmico / Morfina Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Precondicionamento Isquêmico / Morfina Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil