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1-n-Hexadecyl-3-methylimidazolium methanesulfonate and chloride salts with effective activities against Candida tropicalis biofilms.
Bergamo, V Z; Balbueno, E A; Hatwig, C; Pippi, B; Dalla Lana, D F; Donato, R K; Schrekker, H S; Fuentefria, A M.
Afiliação
  • Bergamo VZ; Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Balbueno EA; Laboratory of Applied Mycology, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Hatwig C; Laboratory of Applied Mycology, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Pippi B; Laboratory of Applied Mycology, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Dalla Lana DF; Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Donato RK; Laboratory of Applied Mycology, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Schrekker HS; Laboratory of Applied Mycology, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
  • Fuentefria AM; Laboratory of Technological Processes and Catalysis, Institute of Chemistry, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil.
Lett Appl Microbiol ; 61(5): 504-10, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26331427
UNLABELLED: Although the use of catheters in critically ill patients is mostly inevitable, this invasive procedure comes together with several health risks. Within this context, the contamination with Candida tropicalis is a primary concern as this highly prevalent pathogenic yeast can develop an extensive polymeric matrix that hinders the drugs' penetration and its effective treatment. This study addresses the potential for the 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C16 MImMeS) and chloride (C16 MImCl) salts for eliminating the viable cells of biofilms of Candida tropicalis, compared to the performance of chlorhexidine (CHX) and fluconazole (FLZ). The minimum concentration required of C16 MImMeS, C16 MImCl, CHX and FLZ for elimination of the biofilm's viable cells (MBEC) was evaluated through microtitre plate biofilm exposure with different concentrations of these substances. These concentrations were determined at 80% of effective activity against the biofilm's viable cells by using the MTT reduction assay. C16 MImMeS and C16 MImCl were able to eliminate the viable cells at much lower concentrations (15·6 and 0·45 µg ml(-1) respectively) than CHX (1250 µg ml(-1) ) and FLZ (resistance of the viable cells). This demonstrates the high potential of these substances for nosocomial infections control. SIGNIFICANCE AND IMPACT OF THE STUDY: The 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C16 MImMeS) and chloride (C16 MImCl) salts are extremely effective in eliminating the viable cells of Candida tropicalis biofilms, which allows the use of much lower concentrations than with the antimicrobial of choice (chlorhexidine) in hospital practices. These findings indicate these imidazolium salts as high-potential candidates for asepsis of medical environments and materials, including implants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofilmes / Candida tropicalis / Infecções Relacionadas a Cateter / Imidazóis Limite: Humans Idioma: En Revista: Lett Appl Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biofilmes / Candida tropicalis / Infecções Relacionadas a Cateter / Imidazóis Limite: Humans Idioma: En Revista: Lett Appl Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido