[Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment]. / Doença de Basedow-Graves: análise de diferentes parâmetros na previsão de remissão após tratamento clínico.
Rev Paul Med
; 107(2): 69-74, 1989.
Article
em Pt
| MEDLINE
| ID: mdl-2629056
Fifty patients with Graves' disease were evaluated in relation to their outcome following medical treatment: goiter size, T3/T4 ratio, TSH and TSAb plasma levels were studied. Patients were followed for 8-20 months of medical treatment with PTU and 24-36 months thereafter. Thirty patients were eliminated for abandoning treatment (50%) or due to PTU side-effects (10%). The 20 patients remaining presented similar remission/relapse rates regardless of their T3/T4 ratio, greater than 20 (21% vs. 79%) or less than 20 (16% vs. 84%). Patients with TSH levels greater than 0.10 uU/ml immediately after PTU withdrawal presented a slight increase of remission rate (30% vs. 10%). Patients with goiter size greater than 60 cm3 at the beginning of medical treatment presented a remission rate of 8%, while those with goiters less than or equal to 60 cm3 showed a remission rate of 50%. Finally, normalization of TSAb levels (less than 15%) occurred at a remission rate of 100%, while all patients who did not achieve this goal relapsed shortly after PTU withdrawal. Based on these results, the authors conclude that the determination of TSAb levels is a reliable parameter of predict remission of Graves' disease following medical treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propiltiouracila
/
Doença de Graves
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pt
Revista:
Rev Paul Med
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Brasil