[The vaccines based on the replicon of the venezuelan equine encephalomyelitis virus against viral hemorrhagic fevers].
Vopr Virusol
; 60(3): 14-8, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-26281301
The status of the various recombinant DNA and RNA-derived candidate vaccines, as well as the Venezuelan equine encephalomyelitis virus (VEEV) replicon vaccine system against extremely hazardous viral hemorrhagic fevers, were reviewed. The VEEV-based replication-incompetent vectors offer attractive features in terms of safety, high expression levels of the heterologous viral antigen, tropism to dendritic cells, robust immune responses, protection efficacy, low potential for pre-existing anti-vector immunity and possibility of engineering multivalent vaccines were tested. These features of the VEEV replicon system hold much promise for the development of new generation vaccine candidates against viral hemorrhagic fevers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Vírus da Encefalite Equina Venezuelana
/
Encefalomielite Equina Venezuelana
/
Febres Hemorrágicas Virais
/
Anticorpos Antivirais
/
Antígenos Virais
Limite:
Animals
/
Humans
País/Região como assunto:
America do sul
/
Venezuela
Idioma:
Ru
Revista:
Vopr Virusol
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Federação Russa