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Association of family risk and lifestyle/comorbidities in ovarian cancer patients.
Teixeira, Natália; Folgueira, Maria Aparecida Azevedo Koike; Maistro, Simone; Encinas, Giselly; Bock, Geertruida Hendrika de; Diz, Maria Del Pilar Estevez.
Afiliação
  • Teixeira N; Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Folgueira MA; Departamento de Radiologia e Oncologia, FM, USP, São Paulo, SP, Brazil.
  • Maistro S; Laboratório de Oncologia Experimental, FM, USP, São Paulo, SP, Brazil.
  • Encinas G; Laboratório de Oncologia Experimental, FM, USP, São Paulo, SP, Brazil.
  • Bock GH; Department of Cancer Epidemiology, University of Groningen, Groningen, Netherlands.
  • Diz Mdel P; Division of Clinical Oncology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992) ; 61(3): 234-9, 2015.
Article em En | MEDLINE | ID: mdl-26248245
OBJECTIVES: to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease. METHODS: in a prospective single center cohort study at the Institute of Cancer of the State of São Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals. RESULTS: seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03). CONCLUSION: in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Cistadenocarcinoma Seroso / Predisposição Genética para Doença / Síndrome Hereditária de Câncer de Mama e Ovário / Hipertensão Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Cistadenocarcinoma Seroso / Predisposição Genética para Doença / Síndrome Hereditária de Câncer de Mama e Ovário / Hipertensão Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil