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17ß-Estradiol and testosterone in sarcopenia: Role of satellite cells.
La Colla, Anabela; Pronsato, Lucía; Milanesi, Lorena; Vasconsuelo, Andrea.
Afiliação
  • La Colla A; INBIOSUR-CONICET, 8000 Bahía Blanca, Argentina.
  • Pronsato L; INBIOSUR-CONICET, 8000 Bahía Blanca, Argentina.
  • Milanesi L; INBIOSUR-CONICET, 8000 Bahía Blanca, Argentina.
  • Vasconsuelo A; INBIOSUR-CONICET, 8000 Bahía Blanca, Argentina.
Ageing Res Rev ; 24(Pt B): 166-77, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26247846
The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsible for muscle perfomance decline. Interestingly, sarcopenia has been associated to a deficit of sex hormones which decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not be possible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They are activated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cells could be a key factor to overcome sarcopenia. Of importance, satellite cells are 17ß-estradiol (E2) and testosterone (T) targets. In this review, we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly. The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Envelhecimento / Células Satélites de Músculo Esquelético / Estradiol / Sarcopenia Limite: Humans Idioma: En Revista: Ageing Res Rev Assunto da revista: GERIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Envelhecimento / Células Satélites de Músculo Esquelético / Estradiol / Sarcopenia Limite: Humans Idioma: En Revista: Ageing Res Rev Assunto da revista: GERIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido