Dextro-phenylalanine as inhibitor of the noradrenaline release from the isolated rat hypothalamus.
Acta Neurol Latinoam
; 25(3-4): 235-48, 1979.
Article
em En
| MEDLINE
| ID: mdl-262354
In slices of isolated rat hypothalamus, the dextrophenylalanine (d-Phe) 3x10(-3)M produced an inhibition of a 47% in the fractional release of 3H-NA to the preparations of Holtzman rats, and of 39% to the Wistar rats, when the concentration of d-Phe (in this last) was of 1x10(-2)M, pointing that the effectiveness of the d-Phe is variable with the employed rat root. The mentioned effect is calcium dependent, for it was antagonized when the Ca++ was incremented in the medium of 1,68mM (normal) to 2,6mM. Neither atropine, nor phenoxybenzamine interfer the effect to the d-Phe, showing that it will not be due to mechanisms of alpha-adrenergic or muscarinic cholinergic negative feedback. For the moment it cannot be interpretated that the d-Phe effect is performed through specific negative feed-back receivers, for the possible operability of other kind of receptors such as PGs angiotensin, morphinic, etc., has not been discarded yet.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Norepinefrina
/
Ácido gama-Aminobutírico
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Acta Neurol Latinoam
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1979
Tipo de documento:
Article
País de publicação:
Uruguai