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Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation.
Rodriguez, G Y; Valverde-Ramírez, M; Mendes, C E; Béttega, R; Badino, A C.
Afiliação
  • Rodriguez GY; Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil.
  • Valverde-Ramírez M; Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil.
  • Mendes CE; Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil.
  • Béttega R; Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil.
  • Badino AC; Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil. badinojr@ufscar.br.
Bioprocess Biosyst Eng ; 38(11): 2063-75, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26227509
Global variables play a key role in evaluation of the performance of pneumatic bioreactors and provide criteria to assist in system selection and design. The purpose of this work was to use experimental data and computational fluid dynamics (CFD) simulations to determine the global performance parameters gas holdup ([Formula: see text]) and volumetric oxygen transfer coefficient (k L a), and conduct an analysis of liquid circulation velocity, for three different geometries of pneumatic bioreactors: bubble column, concentric-tube airlift, and split tube airlift. All the systems had 5 L working volumes and two Newtonian fluids of different viscosities were used in the experiments: distilled water and 10 cP glycerol solution. Considering the high oxygen demand in certain types of aerobic fermentations, the assays were carried out at high flow rates. In the present study, the performances of three pneumatic bioreactors with different geometries and operating with two different Newtonian fluids were compared. A new CFD modeling procedure was implemented, and the simulation results were compared with the experimental data. The findings indicated that the concentric-tube airlift design was the best choice in terms of both gas holdup and volumetric oxygen transfer coefficient. The CFD results for gas holdup were consistent with the experimental data, and indicated that k L a was strongly influenced by bubble diameter and shape.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Água / Reatores Biológicos / Glicerol / Modelos Químicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Água / Reatores Biológicos / Glicerol / Modelos Químicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha