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The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats.
Fortaleza, Eduardo Albino Trindade; Ferreira-Junior, Nilson Carlos; Lagatta, Davi Campos; Resstel, Leonardo Barbosa Moraes; Corrêa, Fernando Morgan Aguiar.
Afiliação
  • Fortaleza EA; Departments of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14090-090, Brazil.
  • Ferreira-Junior NC; Departments of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14090-090, Brazil.
  • Lagatta DC; Departments of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14090-090, Brazil.
  • Resstel LB; Departments of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14090-090, Brazil.
  • Corrêa FM; Departments of Pharmacology, School of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP 14090-090, Brazil. Electronic address: fmdacorr@fmrp.usp.br.
Auton Neurosci ; 193: 44-50, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26213356
The medial amygdaloid nucleus (MeA) is involved in cardiovascular control. In the present study we report the effect of MeA pharmacological ablations caused by bilateral microinjections of the nonselective synaptic blocker CoCl2 on cardiac baroreflex responses in rats. MeA synaptic inhibition evoked by local bilateral microinjection of 100 nL of CoCl2 (1 mM) did not affect blood pressure or heart rate baseline, suggesting no tonic MeA influence on resting cardiovascular parameters. However, 10 min after CoCl2 microinjection into the MeA of male Wistar rats, the reflex bradycardic response evoked by intravenous infusion of phenylephrine was significantly enhanced when compared with the reflex bradycardic response observed before CoCl2. The treatment did not affect the tachycardic responses to the intravenous infusion of sodium nitroprusside (SNP). Baroreflex activity returned to control values 60 min after CoCl2 microinjections, confirming a reversible blockade. The present results indicate an involvement of the MeA in baroreflex modulation, suggesting that synapses in the MeA have an inhibitory influence on the bradycardic component of the baroreflex in conscious rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barorreflexo / Complexo Nuclear Corticomedial Limite: Animals Idioma: En Revista: Auton Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barorreflexo / Complexo Nuclear Corticomedial Limite: Animals Idioma: En Revista: Auton Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda