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EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE.
Marim, Ricardo Guimarães; de Gusmão, Alex Silva; Castanho, Roberto Esteves Pires; Deminice, Rafael; Therezo, Altino Luiz Silva; Jordão Júnior, Alceu Afonso; de Assis, Marcos Renato; Taipeiro, Elane de Fátima; Martins, Luciamare Perinetti Alves.
Afiliação
  • Marim RG; Department of Parasitology, Marília Medical School, Marília, São Paulo, Brazil.
  • de Gusmão AS; Department of Parasitology, Marília Medical School, Marília, São Paulo, Brazil.
  • Castanho RE; Department of Parasitology, Marília Medical School, Marília, São Paulo, Brazil.
  • Deminice R; Department of Medical Clinic, Division of Nutrition and Metabolism, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil.
  • Therezo AL; Department of Pathology, Marília Medical School, Marília, São Paulo, Brazil.
  • Jordão Júnior AA; Department of Medical Clinic, Division of Nutrition and Metabolism, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil.
  • de Assis MR; Department of Rheumatology, Marília Medical School, Marília, São Paulo, Brazil.
  • Taipeiro Ede F; Department of Biochemisty, Marília Medical School, Marília, São Paulo, Brazil.
  • Martins LP; Department of Parasitology, Marília Medical School, Marília, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo ; 57(3): 245-50, 2015.
Article em En | MEDLINE | ID: mdl-26200966
INTRODUCTION: In order to examine the effectiveness of vitamin C (ascorbic acid) in combating the oxidative insult caused by Trypanosoma cruzi during the development of the chronic phase of Chagas disease, Swiss mice were infected intraperitoneally with 5.0 × 104 trypomastigotes of T. cruzi QM1strain. METHODS: Mice were given supplements of two different doses of vitamin C for 180 days. Levels of lipid oxidation (as indicated by thiobarbituric acid reactive substances-TBARS), total peroxide, vitamin C, and reduced glutathione were measured in the plasma, TBARS, total peroxide and vitamin C were measured in the myocardium and histopathologic analysis was undertaken in heart, colon and skeletal muscle. RESULTS: Animals that received a dose equivalent to 500 mg of vitamin C daily showed increased production of ROS in plasma and myocardium and a greater degree of inflammation and necrosis in skeletal muscles than those that received a lower dose or no vitamin C whatsoever. CONCLUSION: Although some research has shown the antioxidant effect of vitamin C, the results showed that animals subject to a 500 mg dose of vitamin C showed greater tissue damage in the chronic phase of Chagas disease, probably due to the paradoxical actions of the substance, which in this pathology, will have acted as a pro-oxidant or pro-inflammatory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Doença de Chagas / Suplementos Nutricionais / Antioxidantes Limite: Animals Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Doença de Chagas / Suplementos Nutricionais / Antioxidantes Limite: Animals Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil