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Metabolic and testicular effects of the long-term administration of different high-fat diets in adult rats.
Campos-Silva, Pamella; Furriel, Angelica; Costa, Waldemar S; Sampaio, Francisco J B; Gregorio, Bianca M.
Afiliação
  • Campos-Silva P; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Brazil.
  • Furriel A; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Brazil.
  • Costa WS; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Brazil.
  • Sampaio FJ; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Brazil.
  • Gregorio BM; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Brazil.
Int Braz J Urol ; 41(3): 569-75, 2015.
Article em En | MEDLINE | ID: mdl-26200553
PURPOSE: To evaluate the effects of different high-fat diets on body mass, carbohydrate metabolism and testicular morphology in rats seven months old. MATERIALS AND METHODS: Male Wistar rats were divided into four groups: SC (standard chow), HF-S (high fat diet rich in saturated fatty acids), HF-P (high fat diet rich in polyunsaturated fatty acids), HF-SP (high fat diet rich in saturated and polyunsaturated fatty acids). The rats were fed for 16 weeks. Blood samples, testes and genital fat deposits were collected for analysis. Data were analyzed by one-way ANOVA and Bonferroni post hoc test, considering p<0.05 as statistically significant. RESULTS: Different high-fat diets promoted an increase in the body mass (p<0.0001). The genital fat deposits were higher in the high-fat groups (HF-S, HF-P, HF-SP) (p=0.0004). Regarding serum parameters, the animals in the HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030) and hypercholesterolemia (p=0.0021). All of the hyperlipidemic groups showed hyperleptinemia (p=0.0019). Concerning the testis, the HF-S group showed a reduction on the seminiferous epithelium height (p=0.0003) and cell proliferation (p=0.0450). Seminiferous tubule diameter was lower in the HF-SP than in the SC group (p=0.0010). CONCLUSIONS: The high fat diet administration, independent of the lipid quality, promotes overweight. Diet rich in saturated fatty acids (lard) alters the carbohydrate metabolism and the testicular morphology with reductions of seminiferous epithelium height, seminiferous tubule diameter and cell proliferation which could be related to a disturbance of spermatogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Carboidratos da Dieta / Dieta Hiperlipídica Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Carboidratos da Dieta / Dieta Hiperlipídica Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil