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Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients.
Brunoni, A R; Lotufo, P A; Sabbag, C; Goulart, A C; Santos, I S; Benseñor, I M.
Afiliação
  • Brunoni AR; Centro de Pesquisa Clínica e Epidemiológica, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Lotufo PA; Centro de Pesquisa Clínica e Epidemiológica, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Sabbag C; Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Goulart AC; Centro de Pesquisa Clínica e Epidemiológica, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Santos IS; Centro de Pesquisa Clínica e Epidemiológica, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
  • Benseñor IM; Centro de Pesquisa Clínica e Epidemiológica, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res ; 48(8): 711-4, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26200230
Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n=94) presenting with psoriasis for at least 1 year were enrolled, and age- and gender-matched with healthy controls (n=307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major depression. BDNF plasma levels were determined using the Promega ELISA kit. A general linear model was used to compare BDNF levels in psoriasis patients and controls, with age, gender, systolic blood pressure, serum fasting glucose, blood lipid levels, triglycerides, smoking status, and body mass index examined. After adjusting for clinical and demographic variables, significantly decreased BNDF plasma levels were observed in psoriasis patients (P=0.01) (estimated marginal means of 3922 pg/mL; 95%CI=2660-5135) compared with controls (5788 pg/mL; 95%CI=5185-6442). Similar BDNF levels were found in both mild and severe cases of psoriasis. Our finding, that BDNF is decreased in psoriasis, supports the concept of a brain-skin connection in psoriasis. Further studies should determine if BDNF is increased after specific psoriasis treatments, and associated with different disease stages.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil