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Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability.
Belangero, Paulo Santoro; Leal, Mariana Ferreira; Cohen, Carina; Figueiredo, Eduardo Antônio; Smith, Marília Cardoso; Andreoli, Carlos Vicente; de Castro Pochini, Alberto; Ejnisman, Benno; Cohen, Moises.
Afiliação
  • Belangero PS; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
  • Leal MF; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
  • Cohen C; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, São Paulo, 04023-001, Brazil.
  • Figueiredo EA; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
  • Smith MC; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, São Paulo, 04023-001, Brazil.
  • Andreoli CV; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, São Paulo, 04023-001, Brazil.
  • de Castro Pochini A; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
  • Ejnisman B; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
  • Cohen M; Departamento de Ortopedia e Traumatologia, Universidade Federal de São Paulo, São Paulo, São Paulo, 04038-031, Brazil.
J Orthop Res ; 34(3): 510-7, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26185036
The molecular alterations involved in the capsule deformation presented in shoulder instability patients are poorly understood. Increased TGFß1 acts as a signal for production of matrix macromolecules by fibrogenic cells at joint injury sites. TGFß1, through its receptor TGFßR1, regulates genes involved in collagen cross-linking, such as LOX, PLOD1, and PLOD2. We evaluated TGFß1, TGFßR1, LOX, PLOD1, and PLOD2 gene expression in the antero-inferior (macroscopically injured region), antero-superior and posterior regions of the glenohumeral capsule of 29 shoulder instability patients and eight controls. We observed that PLOD2 expression was increased in the anterior-inferior capsule region of the patients compared to controls. LOX expression tended to be increased in the posterior portion of patients. Patients with recurrent shoulder dislocation presented upregulation of TGFßR1 in the antero-inferior capsule portion and of PLOD2 in the posterior region. Conversely, LOX was increased in the posterior portion of the capsule of patients with a single shoulder dislocation episode. In the antero-inferior, LOX expression was inversely correlated and TGFßR1 was directly correlated with the duration of symptoms. In the posterior region, PLOD2, TGFß1, and TGFßR1 were directly correlated with the duration of symptoms. In conclusion, PLOD2 expression was increased in the macroscopically injured region of the capsule of patients. Upregulation of TGFß1, TGFßR1, and PLOD2 seems to be related with the maintenance of disease symptoms, especially in the posterior region. LOX upregulation seems to occur only in the initial phase of the affection. Therefore, TGFß1, TGFßR1, LOX, and PLOD2 may play a role in shoulder instability.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Luxação do Ombro / Articulação do Ombro / Colágeno Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Orthop Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Luxação do Ombro / Articulação do Ombro / Colágeno Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Orthop Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos