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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.
Drumond Marra, Hellen Livia; Myczkowski, Martin Luiz; Maia Memória, Cláudia; Arnaut, Débora; Leite Ribeiro, Philip; Sardinha Mansur, Carlos Gustavo; Lancelote Alberto, Rodrigo; Boura Bellini, Bianca; Alves Fernandes da Silva, Adriano; Tortella, Gabriel; Ciampi de Andrade, Daniel; Teixeira, Manoel Jacobsen; Forlenza, Orestes Vicente; Marcolin, Marco Antonio.
Afiliação
  • Drumond Marra HL; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Myczkowski ML; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Maia Memória C; Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Arnaut D; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Leite Ribeiro P; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Sardinha Mansur CG; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Lancelote Alberto R; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Boura Bellini B; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Alves Fernandes da Silva A; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Tortella G; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Ciampi de Andrade D; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil ; Division of Neurological Surgery, Pain Center, Department of Neurology, University of São Paulo, Avenida Dr. Enéa
  • Teixeira MJ; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil ; Division of Neurological Surgery, Pain Center, Department of Neurology, University of São Paulo, Avenida Dr. Enéa
  • Forlenza OV; Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.
  • Marcolin MA; Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil ; Division of Neurological Surgery, Pain Center, Department of Neurology, University of São Paulo, Avenida Dr. Enéa
Behav Neurol ; 2015: 287843, 2015.
Article em En | MEDLINE | ID: mdl-26160997
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Estimulação Magnética Transcraniana / Disfunção Cognitiva / Memória / Córtex Motor Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Behav Neurol Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Estimulação Magnética Transcraniana / Disfunção Cognitiva / Memória / Córtex Motor Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Behav Neurol Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda