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Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes.
Jamilis, Martín; Garelli, Fabricio; Mozumder, Md Salatul Islam; Castañeda, Teresita; De Battista, Hernán.
Afiliação
  • Jamilis M; Group of Control Applications, LEICI, Faculty of Engineering, La Plata National University, CONICET, C.C.91 (1900), La Plata, Argentina. martin.jamilis@ing.unlp.edu.ar.
  • Garelli F; Group of Control Applications, LEICI, Faculty of Engineering, La Plata National University, CONICET, C.C.91 (1900), La Plata, Argentina.
  • Mozumder MS; Department of Biosystems Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
  • Castañeda T; Business Unit Separation and Conversion Technology, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium.
  • De Battista H; Research and Development Center for Industrial Fermentations (CINDEFI), School of Science, La Plata National University, CONICET, 47 and 115, B1900ASH, La Plata, Argentina.
Bioprocess Biosyst Eng ; 38(10): 1903-14, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26149912
This paper addresses the estimation of the specific production rate of intracellular products and the modeling of the bioreactor volume dynamics in high cell density fed-batch reactors. In particular, a new model for the bioreactor volume is proposed, suitable to be used in high cell density cultures where large amounts of intracellular products are stored. Based on the proposed volume model, two forms of a high-order sliding mode observer are proposed. Each form corresponds to the cases with residual biomass concentration or volume measurement, respectively. The observers achieve finite time convergence and robustness to process uncertainties as the kinetic model is not required. Stability proofs for the proposed observer are given. The observer algorithm is assessed numerically and experimentally.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbono / Fenômenos Fisiológicos Bacterianos / Reatores Biológicos / Carga Bacteriana / Técnicas de Cultura Celular por Lotes / Modelos Biológicos Tipo de estudo: Risk_factors_studies Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbono / Fenômenos Fisiológicos Bacterianos / Reatores Biológicos / Carga Bacteriana / Técnicas de Cultura Celular por Lotes / Modelos Biológicos Tipo de estudo: Risk_factors_studies Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha