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Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System.
Zimmer, Eduardo R; Leuzy, Antoine; Souza, Diogo O; Portela, Luis V.
Afiliação
  • Zimmer ER; Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), 2600 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil.
  • Leuzy A; Centre for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden.
  • Souza DO; Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), 2600 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil.
  • Portela LV; Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), 2600 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil. roskaportela@gmail.com.
Mol Neurobiol ; 53(6): 3753-3755, 2016 08.
Article em En | MEDLINE | ID: mdl-26141124
In a recent review published in Molecular Neurobiology, Kamat and colleagues (Mol Neurobiol. 2014 Dec;50(3):852-65) highlighted the cellular and molecular mechanisms involved in Okadaic acid (OKA)-induced neurotoxicity. In this review, the authors underline a wide range of pathological signaling pathways involved in OKA-induced neurotoxicity; however, the role of glutamate was only briefly described. We believe that the hyperactivation of the glutamatergic system is a key pathophysiological player in OKA-induced neurotoxicity and deserves serious attention. In this commentary, we propose an integrative model linking glutamate and PP2A and put forward some unanswered questions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Inibidores Enzimáticos / Proteína Fosfatase 2 Limite: Animals / Humans Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Inibidores Enzimáticos / Proteína Fosfatase 2 Limite: Animals / Humans Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos