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Acute restraint stress reduces hippocampal oxidative damage and behavior in rats: Effect of S-allyl cysteine.
Colín-González, Ana Laura; Becerríl, Hugo; Flores-Reyes, Bianca Rubí; Torres, Ismael; Pinzón, Enrique; Santamaría-Del Angel, Daniel; Túnez, Isaac; Serratos, Iris; Pedraza-Chaverrí, José; Santamaría, Abel; Maldonado, Perla D.
Afiliação
  • Colín-González AL; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
  • Becerríl H; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
  • Flores-Reyes BR; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
  • Torres I; Unidad de Bioterio, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Pinzón E; Unidad de Bioterio, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Santamaría-Del Angel D; Laboratorio de Neuroquímica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Túnez I; Departmento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofia/Universidad de Córdoba, Cordoba, Spain; Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Me
  • Serratos I; Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico.
  • Pedraza-Chaverrí J; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Santamaría A; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico. Electronic address: absada@yahoo.com.
  • Maldonado PD; Laboratorio de Patología Vascular, Instituto Nacional de Neurología y Neuocirugía, Mexico City, Mexico.
Life Sci ; 135: 165-72, 2015 Aug 15.
Article em En | MEDLINE | ID: mdl-26135627
AIMS: This simple study was designed to investigate whether acute restraint stress can generate changes in behavioral tests and hippocampal endpoints of oxidative stress in rats, and if the antioxidant S-allyl cysteine (SAC) can prevent these alterations. MATERIALS AND METHODS: We evaluated motor activity, forced swimming and anxiety behavior, as well as the hippocampal levels of lipid peroxidation and the activities of glutathione-related enzymes in animals submitted to mild immobilization. The effect of SAC (100 mg/kg, i.p.), given to rats every day 30 min before starting the immobilization session, was also investigated. Immobilization (restraint) stress was induced for a period of 6 h per day for five consecutive days. KEY FINDINGS: Our results indicate that, under the tested conditions, acute restraint stimulates compensatory behavioral tasks (motor activity, anxiety and forced swimming) to counteract the stressing conditions prevailing, and selectively increased the levels of lipid peroxidation and the enzyme activities of glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the hippocampus also as adaptive responses. SAC exhibited preventive effects in the stressed group as it improved behavior, reduced lipid peroxidation and prevented the increase of GST and GPx activities, suggesting that this antioxidant blunted primary pro-oxidative stimuli induced by restraint stress. SIGNIFICANCE: Findings of this work also confirm that the use of antioxidants such as SAC can provide effective protection against the acute oxidative damage associated with anxiety produced by stressing conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Estresse Oxidativo / Cisteína / Hipocampo / Atividade Motora / Antioxidantes Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Estresse Oxidativo / Cisteína / Hipocampo / Atividade Motora / Antioxidantes Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Holanda