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Resistance of infection by Plasmodium vivax to chloroquine in Bolivia.
Añez, Arletta; Moscoso, Manuel; Laguna, Ángel; Garnica, Cecilia; Melgar, Viviana; Cuba, Mauren; Gutierrez, Sonia; Ascaso, Carlos.
Afiliação
  • Añez A; Departamento de Salud Pública, Universidad de Barcelona, Barcelona, Spain. arlettarocio@gmail.com.
  • Moscoso M; Organización Panamericana de Salud, Oficina de país Bolivia, La Paz, Bolivia. arlettarocio@gmail.com.
  • Laguna Á; Laboratorio de control de calidad de medicamentos y toxicología del Instituto Nacional de laboratorios en Salud, CONCAMYT-INLASA, La Paz, Bolivia. molomos@yahoo.es.
  • Garnica C; Laboratorio de control de calidad de medicamentos y toxicología del Instituto Nacional de laboratorios en Salud, CONCAMYT-INLASA, La Paz, Bolivia. aplaguna@hotmail.com.
  • Melgar V; Laboratorio de control de calidad de medicamentos y toxicología del Instituto Nacional de laboratorios en Salud, CONCAMYT-INLASA, La Paz, Bolivia. cgarnicalopez@yahoo.es.
  • Cuba M; Laboratorio de control de calidad de medicamentos y toxicología del Instituto Nacional de laboratorios en Salud, CONCAMYT-INLASA, La Paz, Bolivia. irvime@yahoo.es.
  • Gutierrez S; Centro de Salud Rene Salazar, Gerencia de salud Riberalta-Beni, Beni, Bolivia. maurencc@hotmail.com.
  • Ascaso C; Centro de Salud La Unidad, Gerencia de salud Riberalta-Beni, Beni, Bolivia. higueras_74@hotmail.com.
Malar J ; 14: 261, 2015 Jul 01.
Article em En | MEDLINE | ID: mdl-26126708
BACKGROUND: Chloroquine (CQ) over three days plus primaquine (PQ) for seven days is the treatment of choice of infections by Plasmodium vivax in Bolivia, where 95% of the cases of malaria are attributed to this species. The aim of this study was to evaluate the therapeutic efficacy of CQ in this setting. METHODS: Patients in the Amazon region of northern Bolivia, were included in the study from May to November 2011 and the therapeutic efficacy of CQ was evaluated over a 28-day follow-up period. Patients with P. vivax mono-infection received 25 mg/Kg body weight of CQ over three days. The concentrations of CQ + desethylchloroquine (DCQ) in blood were determined at days 7 and 28 of follow up; at follow-up and on the day of treatment failure was administered PQ. RESULTS: One hundred patients fulfilled the inclusion criteria, two were lost to follow up and another two were later excluded for protocol violation. Of the 96 patients who completed the follow up 10 showed TF; one presented continued parasitaemia until day 7 of follow up, three on day 21 and six on day 28 of follow up. The geometric mean of CQ + DCQ on day 7 was 321.7 ng/ml (range 197-535 ng/ml). In six patients with TF the CQ + DCQ concentrations in blood on the day of TF were >100 ng/ml. The rate of resistance was 6.5%. CONCLUSION: The present study demonstrates the presence of resistance to CQ in the treatment of malaria by P. vivax in the Amazon region of Bolivia. New clinical trials are needed to establish alternative treatments against these parasites in this region of South America.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium vivax / Resistência a Medicamentos / Cloroquina / Malária Vivax / Antimaláricos Tipo de estudo: Guideline Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Bolivia Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium vivax / Resistência a Medicamentos / Cloroquina / Malária Vivax / Antimaláricos Tipo de estudo: Guideline Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Bolivia Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha País de publicação: Reino Unido