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Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients.
Cai, X Z; Liu, N; Qiao, Y; Du, S Y; Chen, Y; Chen, D; Yu, S; Jiang, Y.
Afiliação
  • Cai XZ; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China xzcai@mail.cmu.edu.cn.
  • Liu N; Department of Nephrology, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Qiao Y; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Du SY; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Chen Y; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Chen D; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Yu S; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
  • Jiang Y; Central Laboratory, First Affiliated Hospital of China Medical University, Shenyang, China.
Genet Mol Res ; 14(2): 6543-8, 2015 Jun 12.
Article em En | MEDLINE | ID: mdl-26125859
Increasing evidence shows that TIM-1 and TIM-3 in-fluence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown. Real-time transcription-polymerase chain reaction analysis was used to deter-mine expression levels of TIM-1 and TIM-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 36 patients with minimal change glo-merulopathy (MCG), 65 patients with lupus nephritis (LN), 78 patients with IgA nephropathy (IgAN), 55 patients with membranous nephropa-thy (MN), 22 patients with crescentic glomerulonephritis (CGN), 26 patients with anaphylactoid purpura nephritis (APN), and 63 healthy controls. TIM-3 mRNA expression significantly decreased in PBMCs from nephritic patients (LN, P < 0.0001; MCG, P < 0.0001; MN, P = 0.0031; CGN, P = 0.0464; IgAN, P = 0.0002; APN, P = 0.0392) com-pared with healthy controls. In contrast, there was no significant differ-ence in TIM-1 mRNA expression between the patients and the healthy controls. Our results suggest that insufficient expression of TIM-3 mRNA may be involved in the pathogenesis of nephropathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Virais / Nefrite Lúpica / Glicoproteínas de Membrana / Glomerulonefrite por IGA / Proteínas de Membrana Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Virais / Nefrite Lúpica / Glicoproteínas de Membrana / Glomerulonefrite por IGA / Proteínas de Membrana Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil