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Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China.
Fang, Y; Yang, H Y; Shi, Y H; Cui, J H; Li, L Y; Xu, Y C; Shao, J L.
Afiliação
  • Fang Y; Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Yang HY; Kunming Maternal and Child Health Center, Kunming, Yunnan Province, China.
  • Shi YH; Clinical Laboratory Department, Cancer Hospital of Shanxi, Taiyuan, Shanxi, China.
  • Cui JH; Department of Medical Service, PLA Unit 65176, Dalian, Liaoning, China.
  • Li LY; Department of Cardiology and Clinical Laboratory Department, 211th Hospital of the PLA, Harbin, Heilongjiang, China.
  • Xu YC; Department of Cardiology and Clinical Laboratory Department, 211th Hospital of the PLA, Harbin, Heilongjiang, China.
  • Shao JL; Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China jianlinshaoydyy@163.com.
Genet Mol Res ; 14(2): 5031-43, 2015 May 12.
Article em En | MEDLINE | ID: mdl-26125695
Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant normal tissues for 79 Chinese patients with lung cancer were analyzed in this study. Our results indicated that the higher detected frequency of haplogroups prevalent in southern East Asia (53.16%; 42/79) versus those of northern East Asia in the studied population supported the southern East Asian characteristics of the Chinese lung cancer group. Further statistical analysis revealed that the haplogroups F* and G* contributed to the susceptibility to lung cancer in Chinese patients. In addition, by comparing sequences from different tissues of the same patients, a total of eight somatic mutations from six patients were detected. Combined with the fourteen somatic mutations identified in our previous study, the somatic mutation spectrum of the 79 Chinese patients with lung cancer was 25.32% (20/79). Our results suggest that mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Yunnan, Southwest China, and that somatic mitochondrial DNA mutations in the displacement loop can serve as potential biomarkers for clinical utility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / DNA Mitocondrial / Predisposição Genética para Doença / Genoma Mitocondrial / Neoplasias Pulmonares / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haplótipos / DNA Mitocondrial / Predisposição Genética para Doença / Genoma Mitocondrial / Neoplasias Pulmonares / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil