Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia.
Arq Neuropsiquiatr
; 73(6): 516-9, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26083888
OBJECTIVE: To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity. METHOD: A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters. RESULTS: The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time. CONCLUSION: Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Sistema Hipotálamo-Hipofisário
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Distúrbios do Início e da Manutenção do Sono
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Alemanha