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The differences of clinicopathological factors for breast cancer in respect to time of recurrence and effect on recurrence-free survival.
Oven Ustaalioglu, B B; Balvan, O; Bilici, A; Develi, A; Aliustaoglu, M; Vardar, F A; Erkol, B.
Afiliação
  • Oven Ustaalioglu BB; Department of Medical Oncology, HaydarpasaNumuneEducation and Research Hospital, Selimiye Mah, Sair Nesimi sok, Kardesler Apt., No: 1, Daire: 4, Uskudar, 34668, Istanbul, Turkey. basakoven@yahoo.com.
  • Balvan O; Department of Medical Oncology, Dr. LutfiKirdarKartal Education and Research Hospital, Istanbul, Turkey.
  • Bilici A; Department of Medical Oncology, Medipol University, Istanbul, Turkey.
  • Develi A; Department of Medical Oncology, Dr. LutfiKirdarKartal Education and Research Hospital, Istanbul, Turkey.
  • Aliustaoglu M; Department of Medical Oncology, Dr. LutfiKirdarKartal Education and Research Hospital, Istanbul, Turkey.
  • Vardar FA; Department of Pathology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
  • Erkol B; Department of Medical Oncology, HaydarpasaNumuneEducation and Research Hospital, Selimiye Mah, Sair Nesimi sok, Kardesler Apt., No: 1, Daire: 4, Uskudar, 34668, Istanbul, Turkey.
Clin Transl Oncol ; 17(11): 895-902, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26081286
PURPOSE: In the literature, small number of study has addressed time of recurrence in breast cancer. We analyzed clinicopathological factors predicting early or late recurrence in breast cancer patients and also prognostic factors related with recurrence-free survival (RFS) in recurrent patients. PATIENTS/METHODS: We evaluated retrospectively 1980 breast cancer patients. Relapsed was defined as early if it was occured first 5 year of follow-up (Group 1) and late if it was occured after 5 years (Group 2). The clinicopathological factors were compared in respect of time of recurrence. The prognostic factors were evaluated using univariate and multivariate analyses. RESULTS: Recurrence wase detected in 141 patient during follow-up. Tumors recurred after 5 years more likely to have lower stage (p = 0.05), tumors without lymphovascular invasion (LVI) (p < 0.001) and perineural invasion (PNI) (p = 0.01), and also HER2 negative (p < 0.001). The median RFS time and 5 years RFS rates were 42.9 months and 31.9 %, respectively. LVI (p = 0.01), PNI (p = 0.03), HER2 (p = 0.003), progesterone receptor (PR) (p = 0.04), the presence of neoadjuvant chemotherapy (p = 0.003), adjuvant hormonotherapy (p = 0.05) were found to be related with RFS. Axillary lymph node metastasis (p = 0.05) and the presence of PNI (p = 0.009) were poor prognostic factors for early recurrent group. PR-positive tumors (p = 0.001) and luminal subtypes (p = 0.03) had instances of late recurrences significantly. CONCLUSIONS: Clinicopathological factors predicting the recurrence time in breast cancer were important to modify adjuvant therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Itália
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Itália