A correlation of measles specific antibodies and the number of plasmacytoid dendritic cells is observed after measles vaccination in 9 month old infants.
Hum Vaccin Immunother
; 11(7): 1762-9, 2015.
Article
em En
| MEDLINE
| ID: mdl-26075901
Measles virus (MeV) represents one of the main causes of death among young children, particularly in developing countries. Upon infection, MeV controls both interferon induction (IFN) and the interferon signaling pathway which results in a severe host immunosuppression that can persists for up to 6 mo after infection. Despite the global biology of MeV infection is well studied, the role of the plasmacytoid dendritic cells (pDCs) during the host innate immune response after measles vaccination remains largely uncharacterized. Here we investigated the role of pDCs, the major producers of interferon in response to viral infections, in the development of adaptive immune response against MeV vaccine. We report that there is a strong correlation between pDCs population and the humoral immune response to Edmonston Zagreb (EZ) measles vaccination in 9-month-old mexican infants. Five infants were further evaluated after vaccination, showing a clear increase in pDCs at baseline, one week and 3 months after immunization. Three months postvaccination they showed increase in memory T-cells and pDCs populations, high induction of adaptive immunity and also observed a correlation between pDCs number and the humoral immune response. These findings suggest that the development and magnitude of the adaptive immune response following measles immunization is directly dependent on the number of pDCs of the innate immune response.
Palavras-chave
(-) ssRNA, nonsegmented negative single-stranded RNA; DCs, dendritic cells; EZ, Edmonston Zagreb; GMT, Geometric mean titers; IFN, interferon; MMR, measles, mumps, rubella vaccine; MeV, Measles virus; PBMCs, peripheral blood mononuclear cells; PRN, plaque reduction neutralization; cellular and humoral immunity; mDCs, myeloid dendritic cells; measles vaccine; pDCs, plasmacytoid dendritic cells; plasmacytoid dendritic cells
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Vacina contra Sarampo
/
Sarampo
/
Anticorpos Antivirais
Limite:
Adult
/
Female
/
Humans
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Infant
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Hum Vaccin Immunother
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Estados Unidos