Your browser doesn't support javascript.
loading
Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons.
Fortuna, Vitor; Pardanaud, Luc; Brunet, Isabelle; Ola, Roxana; Ristori, Emma; Santoro, Massimo M; Nicoli, Stefania; Eichmann, Anne.
Afiliação
  • Fortuna V; Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA; Health Science Institute, Federal University of Bahia, Salvador 40110-902, Brazil.
  • Pardanaud L; CNRS UMR7241, INSERM U1050, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Paris 75005, France.
  • Brunet I; CNRS UMR7241, INSERM U1050, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Paris 75005, France.
  • Ola R; Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Ristori E; Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Santoro MM; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy; VIB Vesalius Research Center, KU Leuven, 3000 Leuven, Belgium.
  • Nicoli S; Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: stefania.nicoli@yale.edu.
  • Eichmann A; Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA; CNRS UMR7241, INSERM U1050, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Paris 75005, France; Department of Cellular and Molecular Physio
Cell Rep ; 11(11): 1786-96, 2015 Jun 23.
Article em En | MEDLINE | ID: mdl-26074079
The sympathetic nervous system controls smooth muscle tone and heart rate in the cardiovascular system. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. Here, we use the zebrafish embryo to ask whether the DA is required for SN development. We show that noradrenergic (NA) differentiation of SN precursors temporally coincides with vascular mural cell (VMC) recruitment to the DA and vascular maturation. Blocking vascular maturation inhibits VMC recruitment and blocks NA differentiation of SN precursors. Inhibition of platelet-derived growth factor receptor (PDGFR) signaling prevents VMC differentiation and also blocks NA differentiation of SN precursors. NA differentiation is normal in cloche mutants that are devoid of endothelial cells but have VMCs. Thus, PDGFR-mediated mural cell recruitment mediates neurovascular interactions between the aorta and sympathetic precursors and promotes their noradrenergic differentiation.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Fibras Simpáticas Pós-Ganglionares / Células Endoteliais / Neurogênese / Células-Tronco Neurais / Neurônios Adrenérgicos Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Fibras Simpáticas Pós-Ganglionares / Células Endoteliais / Neurogênese / Células-Tronco Neurais / Neurônios Adrenérgicos Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos